Inflammatory and immune pathways in the pathogenesis of periodontal disease
"There are two common diseases affecting the periodotium. The first is gingivitis, which is defined as inflammation of the gingiva in which the connective tissue attachment to the tooth remains at its original level. The disease is limited to the soft-tissue compartment of the gingival epithelium and connective tissue. The second is periodontitis, which is an inflammation of the supporting tissues of the teeth with progressive attachment loss and bone destruction. Both diseases and their symptoms are very common in populations worldwide. In the USA, adolescents have gingivitis and signs of gingival bleeding, whereas 54% of the adult population in the USA exhibits gingival bleeding. Thirty-seven per cent of the adult population in the USA suffers from severe periodontitis. In both cases, the disease is associated with the accumulation of bacteria at the dento-gingival margin, while the causal relationship of specific organisms is not fully clear. The host responds to microbial challenge by generating an inflammatory cell infiltrate in the tissue sub adjacent to the periodontal pocket."
Read More