"Urinary 11-dehydro-thromboxand B2 levels are associated with vascular inflammation and prognosis in atherosclerotic cardiovascular disease."

“Recently published secondary analyses of cardiovascular trials provide the first randomized evidence that daily aspirin use may also reduce the incidence of all cancers combined, even at low doses (75-100 mg daily)”

“10% reduction in overall cancer incidence beginning during the first 10 years of treatment could tip the balance of benefits and risks favourably in average-risk populations.”

“Enhanced platelet activation occurs in colorectal cancer patients. Permanent inactivation of platelet COX-1 by low dose aspirin might restore anti tumor reactivity.”

“The results of clinical studies have shown that the antiplatelet drug aspirin reduces the incidence of vascular events and colorectal cancer.”

“Low-dose aspirin treatment (which is associated with a preferential inhibition of platelet COX-1) causes a 70-80% reduction of urinary 11-dehydro-TXB2  and 2,3-din-or-TXB2 excretion.”

“Both the walnut and fish diets inhibited prostaglandin E metabolite (PGEM) and 11-dehydro thromboxane B2, but had no effect on IL-1β, IL-6, TNF-α, CRP, or the number of circulating lymphocyte subsets.”

“A plant-based diet is associated with decreased risk for cancer and other chronic diseases, due in part to reduced chronic inflammation.”

“Increased cyclooxygenase (COX)-2 expression has been described in a variety of human cancers, which has focused attention on TXA2 as a downstream metabolite of the COX-2-derived PGH2.”

“It is a great importance to further determine whether and how prostanoids, such as TXA2, mediate the effects of COX-2 in cancer, potentially leading to a more targeted approach for cancer prevention and treatment

“Given that certain polyphenols are known to affect more than one protein, it is necessary consider possibility that any single com- pound may affect multiple mechanisms.”

“The mean hs-CRP concentration was not significantly different between the two groups of subjects.”

“We found that the 11-DTXB2 concentration was about 24%greater in smokers than in non-smokers, supporting the use of 11-DTXB2 as a potential biomarker for smoking and CVD.”