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Resources

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Chronic Inflammation Resources

The role of chronic inflammation in wellness and the development and progression of chronic disease is becoming more evident every day. Information sources from peer-reviewed medical publications to social media continue to be filled with new information. We are dedicated to sharing information pertaining to chronic inflammation from reliable sources.

Curcumin May Help Lower Inflammation in metabolic syndrome

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Prostaglandins & Other Lipid Mediators

"Urinary 11-dehydro-thromboxand B2 levels are associated with vascular inflammation and prognosis in atherosclerotic cardiovascular disease."

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The role of aspirin in cancer prevention

“Recently published secondary analyses of cardiovascular trials provide the first randomized evidence that daily aspirin use may also reduce the incidence of all cancers combined, even at low doses (75-100 mg daily)”

“10% reduction in overall cancer incidence beginning during the first 10 years of treatment could tip the balance of benefits and risks favourably in average-risk populations.”

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Platelet activation in patients with colorectal cancer

“Enhanced platelet activation occurs in colorectal cancer patients. Permanent inactivation of platelet COX-1 by low dose aspirin might restore anti tumor reactivity.”

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Role of platelets in inflammation and cancer; novel therapeutic strategies

“The results of clinical studies have shown that the antiplatelet drug aspirin reduces the incidence of vascular events and colorectal cancer.”

“Low-dose aspirin treatment (which is associated with a preferential inhibition of platelet COX-1) causes a 70-80% reduction of urinary 11-dehydro-TXB2  and 2,3-din-or-TXB2 excretion.”

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Communicating clinical research to reduce cancer risk through diet: Walnuts as a case example

“Both the walnut and fish diets inhibited prostaglandin E metabolite (PGEM) and 11-dehydro thromboxane B2, but had no effect on IL-1β, IL-6, TNF-α, CRP, or the number of circulating lymphocyte subsets.”

“A plant-based diet is associated with decreased risk for cancer and other chronic diseases, due in part to reduced chronic inflammation.”

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The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis

“Increased cyclooxygenase (COX)-2 expression has been described in a variety of human cancers, which has focused attention on TXA2 as a downstream metabolite of the COX-2-derived PGH2.”

“It is a great importance to further determine whether and how prostanoids, such as TXA2, mediate the effects of COX-2 in cancer, potentially leading to a more targeted approach for cancer prevention and treatment

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Molecular targets of dietary polyphenols with anti-inflammatory properties

“Given that certain polyphenols are known to affect more than one protein, it is necessary consider possibility that any single com- pound may affect multiple mechanisms.”

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Impact of commonly prescribed exercise interventions on platelet activation in physically inactive and overweight men

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A Japanese cross-sectional multicenter study of biomarkers associated with cardiovascular disease in smokers and non-smokers

“The mean hs-CRP concentration was not significantly different between the two groups of subjects.”

“We found that the 11-DTXB2 concentration was about 24%greater in smokers than in non-smokers, supporting the use of 11-DTXB2 as a potential biomarker for smoking and CVD.”

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