11-dehydro-thromboxane b2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.
“In addition to TXA2, which is capable of causing bronchoconstriction, lasma extravasation, and chemokine expression, its stable metabolite 11-dehydro-TXB2 might also be directly involved in the recruitment of ecosinophils, basophils and presumably TH2 lymphocytes to sites of inflammation.”
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