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Peripheral Arterial Disease

Diabetes mellitus, hypercholesterolemia, and hypertension but not vascular disease per se are associated with persistent platelet activation in vivo

"Previous studies relating increased thromboxane (TX) biosynthesis to cardiovascular risk factors do not answer the question whether platelet activation is merely a consequence of more prevalent atherosclerotic lesions or reflects the influence of metabolic and hemodynamic disturbances on platelet biochemistry and function."

"The occurrence of large-vessel peripheral arterial disease per se is not a trigger of platelet activation in vivo.  Rather, the rate of TXA2 biosynthesis appears to reflect the influence of coexisting disorders such as diabetes mellitus, hypercholesterolemia, and hypertension on platelet biochemistry and function.  Enhanced TXA2 biosynthesis may represent a common link between such diverse risk factors and the thrombotic complications of peripheral arterial disease."

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Inflammation and platelet activation in peripheral arterial occlusive disease.

"Epidemiological evidence indicates that inflammation accompanies the progression of atherosclerosis.  The aim of the present cross-sectional study was to define relationships between platelet activation and inflammation in patients with mild to severe (stages II to IV) peripheral arterial occlusive disease (PAOD) and matched controls.  The effect of chronic administration of low-dose acetylsalicylic acid was investigated."

“A positive correlation between 11-DHTXB2 and CRP was found in the study population.”

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