The influence of low-grade inflammation on platelets in patients with stable coronary artery disease.
"Inflammation is likely to be involved in all stages of atherosclerosis. Numerous inflammatory biomarkers are currently being studied, and even subtle increases in inflammatory biomarkers have been associated with increased risk of cardiovascular events in patients with coronary artery disease (CAD). Low-grade inflammation may influence both platelet production and platelet activation potentially leading to enhanced platelet aggregation."
"Increased levels of hsCRP and IL-6 were independently associated with increased platelet aggregation and urine-11-dehydrothromboxane B2 levels (110). This association may be explained by aspirin-insensitive thromboxane generation derived from cyclooxygenase-2 in non-platelet cells."
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