Simple, Non-Invasive Testing
The user-friendly Chronic Inflammation Test measures a thromboxane metabolite in your urine. It quantifies your results with a more specific score that will assist in managing chronic inflammation in your body.
What the Test Measures
The Chronic Inflammation Test is an immunoassay that determines 11-dehydrothromboxane B2 in urine. The 11-dehydrothromboxane B2 level measures thromboxane A2 production associated with inflammation in the body. A urine creatinine test is also performed to calculate a ratio (11-dehydrothromboxane B2/creatinine) and standardize the test for urine concentration. This permits the test to be performed on a random sample.
The urinary 11-dehydrothromboxane B2 is produced by COX 1 & 2 activity on arachidonic acid (Omega-6 fatty acid). Increased 11-dehydrothromboxane B2 has been associated with disorders such as heart disease, peripheral artery disease, stroke, diabetes, cancer, Alzheimer’s disease, and hypertension. Smoking and obesity frequently raise the 11-dehydrothromboxane B2 level.
What is the Chronic Inflammation Score?
The Chronic Inflammation Score is determined by first calculating the ratio of pg 11-dehydrothromboxane B2/mg/dl creatinine. That ratio is then divided by 10. The reference range for the test score is 141-421.
The definition of cellular inflammation is increased activity of the gene transcription factor know as Nuclear Factor-kappaB (NF-κB) … This also means that appropriate use of the diet can either turn on or turn off the activation of NF-κB. This new knowledge is the foundation of anti-inflammatory nutrition.
All of the knowledge that we have gained over the years has now come together to one central theme. Most chronic diseases, including cancer, result from inflammation. Reducing inflammation reduces all kinds of problems. Our efforts must be focused in that direction.
The presence of inflammation is what makes most disease perceptible to an individual … How long it has been smoldering really determines the degree of severity of a disease and often the prognosis assuming the inflammation can be controlled.
...uncontrolled inflammation plays a role in almost every major disease, including cancer, heart disease, Alzheimer’s disease and even depression.
As a doctor, my job is to find those inflammatory factors unique to each person and to see how various lifestyle, environmental, or infectious factors spin the immune system out of control, leading to a host of chronic illnesses.