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11-dehydro-thromboxane b2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.

“In addition to TXA2, which is capable of causing bronchoconstriction, lasma extravasation, and chemokine expression, its stable metabolite 11-dehydro-TXB2 might also be directly involved in the recruitment of ecosinophils, basophils and presumably TH2 lymphocytes to sites of inflammation.”

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Correlation between the clinical effects of seratrodast and the level of 11-dehydrothromboxane B2 in urine/sputum in bronchial asthma patients

"An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2.  The compound has a bicyclic oxaneoxetane structure.  It is a potent inducer of platelet aggregation and causes vasoconstriction.  It is the principal component of rabbit aorta contracting substance ORCS)."

"These results suggest that bronchial asthma patients with high urinary 11-DHTXB2 levels could markedly respond to Seratrodast treatment. ”

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Determinants of platelet activation in Alzheimer’s disease

"This study is to investigate the rate of platelet thromboxane (TX) biosynthesis and its determinants in Alzheimer's disease.

“Urinary 11-dehydroTXB2 and 8-iso-PGF2a were significantly higher in Alzheimer patients than in controls”

“No difference was found in CRP, TNF-a and IL-6 levels between the two groups.”

“Platelet activation is persistently enhanced in Alzheimer’s disease.”

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