“In addition to TXA2, which is capable of causing bronchoconstriction, lasma extravasation, and chemokine expression, its stable metabolite 11-dehydro-TXB2 might also be directly involved in the recruitment of ecosinophils, basophils and presumably TH2 lymphocytes to sites of inflammation.”Read More
"An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance ORCS)."
"These results suggest that bronchial asthma patients with high urinary 11-DHTXB2 levels could markedly respond to Seratrodast treatment. ”Read More
"This study is to investigate the rate of platelet thromboxane (TX) biosynthesis and its determinants in Alzheimer's disease.
“Urinary 11-dehydroTXB2 and 8-iso-PGF2a were significantly higher in Alzheimer patients than in controls”
“No difference was found in CRP, TNF-a and IL-6 levels between the two groups.”
“Platelet activation is persistently enhanced in Alzheimer’s disease.”Read More