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Enhanced thromboxane biosynthesis in patients with chronic obstructive pulmonary disease

“The urinary excretion of 11-dehydro-TxB2 was significantly higher in patients with COPD than in control subjects. Moreover, 11-dehydro-TxB2 excretion was inversely related with arterial oxygen tension.”

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Inflammation and platelet activation in peripheral arterial occlusive disease.

"Epidemiological evidence indicates that inflammation accompanies the progression of atherosclerosis.  The aim of the present cross-sectional study was to define relationships between platelet activation and inflammation in patients with mild to severe (stages II to IV) peripheral arterial occlusive disease (PAOD) and matched controls.  The effect of chronic administration of low-dose acetylsalicylic acid was investigated."

“A positive correlation between 11-DHTXB2 and CRP was found in the study population.”

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Mechanisms of atherothrombosis in chronic obstructive pulmonary disease.

"Chronic obsructive pulmonary disease (COPD) is a leading cause of death worldwide. (Calverley and Walker 2003) In addition to the healthcare costs, COPD imposes a significant burden in terms of disability and impaired quality of life.  Unlike many other leading causes of death and disability, COPD prevalence will raise in the majority of countries as smoking frequency increses and the population ages. (Halbert et al 2006). The World Health Organization predicts that by 2020 COPD will be the 5th most prevalent disease worldwide and the 3rd most common cause of death. "

“CPR upregulates the production of pro-inflammatory cytokines and tissue factor by monocytes, increases the uptake of low-density lipoproteins (LDL by macrophages with foam cells formation and directly induces expression of adhesion molecules by human endothelial cells.”

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Prostanoid and TP-receptors in atherothrombosis: Is there a role for their antagonism?

"Atherosclerosis and its clinical manifestations (i.e. myocardial infarction, stroke) are major causes of mortality and morbidity in Western countries.  Atherogenesis is a pathological process characterised by the deposition of lipids and other blood-borne materials in the arterial wall.  Endothelial dysfunction is considered the first step in the cascade leading up to coronary events."

“Dysfunctional endothelium, characterized by increased COX-activity, releases prostanoids that promote endothelial exposure to adhesion molecules and induce smooth muscle cell contraction.”

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Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population.

"Resistance to inhibition of platelet function by aspirin may contribute to future myocardial infarction and stroke.  Adverse cardiovascular outcomes have been associated with aspirin resistance on several different platelet function assays, including the level of urinary 11-dehydro thromboxane B2 (Tx-M), platelet aggregation to arachidonic acid and adenosine diphosphate, and closure time on the platelet function analyzer-100.  We examined the concordance of these aspirin-resistance assays and their relation to cardiovascular risk factors in a primary prevention population."

“Aspirin resistance by platelet function analyzer-100 was associated only with increased von Willebrand factor levels and not with atherosclerotic risk profile.”

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11-dehydro-thromboxane b2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.

“In addition to TXA2, which is capable of causing bronchoconstriction, lasma extravasation, and chemokine expression, its stable metabolite 11-dehydro-TXB2 might also be directly involved in the recruitment of ecosinophils, basophils and presumably TH2 lymphocytes to sites of inflammation.”

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Correlation between the clinical effects of seratrodast and the level of 11-dehydrothromboxane B2 in urine/sputum in bronchial asthma patients

"An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2.  The compound has a bicyclic oxaneoxetane structure.  It is a potent inducer of platelet aggregation and causes vasoconstriction.  It is the principal component of rabbit aorta contracting substance ORCS)."

"These results suggest that bronchial asthma patients with high urinary 11-DHTXB2 levels could markedly respond to Seratrodast treatment. ”

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Determinants of platelet activation in Alzheimer’s disease

"Thhis study is to investigate the rate of platelet thromboxane (TX) biosynthesis and its determinants in Alzheimer's disease.

“Urinary 11-dehydroTXB2 and 8-iso-PGF2a were significantly higher in Alzheimer patients than in controls”

“No difference was found in CRP, TNF-a and IL-6 levels between the two groups.”

“Platelet activation is persistently enhanced in Alzheimer’s disease.”

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