"The results of this study suggest that nicotinic acid increases thromboxane and leukotriene synthesis which may not be beneficial for patients with cardiovascular diseases or asthma.  In contrast, the increase of prostacyclin production and the inhibition in thromboxane and leukotriene synthesis by pyriodoxine might be beneficial in disorders where the production of prostacyclin is decreased and the formation of thromboxane and cysteinyl leukotrienes is enhanced.

"The treatment with nicotinic acid increased 11-DHTXB₂ excretion to 2.6 fold and leukotriene E4 excretion to twice the basal values."

“Women with android obesity had higher levels of 8-iso PGF2alpha and 11-dehydro-TxB₂ than nonobese women.” 

“Both 8-iso PGF2alpha and 11-dehydroTxB₂ were higher in women with android obesity than women with gynoid obesity” 

“Of 20 women with android obesity, 11 achieved successful weight loss, which was associated with statistically significant reductions in C-reactive protein (median change 23%  p<.05), 8-iso PGF2alpha (median change 32%  p=.04) and 11-dehydro-TXB2 (median change 54% p=.005)." 

"This study investigated the effects of smoking cessation with and without nicotine substitution on the excretion of major urinary metabolites of thromboxane A₂ and prostacyclin; 11-dehydrothromboxane B₂ and 2, 3-dinor-6ketoprostaglandin F1 alpha, respectively, as well as on the excretion of leukotriene E4 in man."

"The fact that eicosanoid production remains at pre-cessation levels in volunteers who quit smoking but use nicotine substitution may be involved in the risk of cardiovascular complications reported during nicotine replacement therapy."

"In the 24 patients in whom the plaque score was measured, multivariate analysis indicated a significant positive correlation between urinary excretion of 11-dehydrothromboxane B₂ and plaque score, age, smoking and hypercholestermia.  Our results indicate the risk factors such as age, hypercholestermia, atherosclerosis and smoking activate platelets in vivo to develop carotid atherosclerosis."

"Multivariate analysis indicated a significant positive correlation between urinary excretion of 11-dehydrothromboxane B₂ and plaque score, age, smoking and hypercholesteremia."

“Cigarette smoking increased the urinary excretion of 11-dehydrothromboxane B₂ (reflecting thromboxane A₂ generation).”

“Cigarette smoking was also associated with higher levels of fibrinogen in plasma.”

“Cigarette smoking and transdermal nicotine treatment were both associated with a higher white blood cell count compared with the placebo patch.”