"Urinary 8-epi-PGF2 alpha level decreased from 450 +/- 170 to 330 +/- 159 Pg/mg creatinine, urinary 11-dehydro-TxB2 level decreased from 1,200 +/- 420 to 790 +/- 320 pg/mg creatinine with no changes in the placebo group."Read More
Complementary & Alternative
Complementary and alternative medicine (CAM) refers to the use of medical products and practices unlike traditional medical practice. Alternative medicine refers to treatments used in place of traditional ones. Complementary medicine refers to non-traditional treatments together with traditional medical practices. Many of the CAM products and treatments that are utilized by healthcare practitioners are known to have a significant effect on the thromboxane A2 pathway and the prevention and reduction of chronic inflammation. Levels of urinary 11-dehydrothromboxane B2 reflect activity of components of the thromboxane A2 pathway that result in thromboxane A2 generation.
"Dietary patterns high in refined starches, sugar, and saturated and trans-fatty acids and poor in natural antioxidants and fiber from fruits, vegetables, and whole grains may cause an activation of the innate immune system, most likely by an excessive reduction of proinflammatory cytokines associated with a reduced production of anti-inflammatory cytokines. This imbalance may favor the generation of a proinflammatory milieu, which in turn produces endothelial dysfunction at the vascular level and ultimately predisposes susceptible people to increased incidence of the metabolic syndrome and CHD."Read More
"High-dose supplements of fish oil reduce thromboxane synthesis in nonpregnant human subjects and were therefore proposed as a means of preventing various small-vessel disorders, including preeclampsia. The effect of fish oil on thromboxane metabolism in pregnancy was investigated in our study."
"A decrease ranging from 32% to 71%, in 24-hour urinary 11-dehydro-thromboxane B2 excretion (mean reduction from 1606 pg/mg creatinine to 779 pg/mg creatinine, p < 0.001) was found among the 11 fish oil-treated women. No change in excretion was found among the control women. No maternal, fetal, or neonatal bleeding disturbances occurred, and no laboratory changes in coagulation markers were observed.”Read More