"There is increasing appreciation of the role of platelets in tumor growth and metastatic dissemination (Gay and Felding-Habermann, 2011). Platelet activiation can lead to the release of growth and angiogenesis factors present in a-granules into the tumor microenvironment. (Italiano et al., 2008). Moreover, platelets and the factors they release can up-regulate cyclooxygenase (COX)-2 which is considered an early event of cell transformation (Patrono et al., 2001). In colorectal cancer, COX-2 expression is induced early in stromal cells and subsequently at high levels in epithelial cells (Prescott, 2000), where it correlates with advanced tumor invasion and poor clinical outcomes (Sheehan et al., 1999)."
"Intestinal tumorigenesis was associated with enhanced urinary TX-M levels, but unaffected by celecoxib, suggesting the involvement of a COX-1-dependent pathway, presumably from platelets."Read More