Thromboxane-dependent CD40 ligand release in type II diabetes mellitus
"The goals of this study were to characterize the platelet contribution to soluble CD-40 ligand (sCD40L), to correlate its formation with the extent of oxidative stress and platelet activation, and to investigate the effects of improved metabolic control and low-dose aspirin on these processes."
“This study provides several lines of evidence for the dependence of sCD40L release on TXA2-dependent platelet activation in T2DM and provides novel mechanistic insight into the amplification loops of persistent platelet activation in this setting.”
Read More