Why Test for Chronic Inflammation?

Chronic diseases, such as Alzheimer’s, cancer, dementia, digestive diseases, heart disease, migraines, autoimmune diseases, and accelerated rate of aging, are responsible for 70 percent of our country’s healthcare costs. Chronic inflammation on a cellular level is the major cause of chronic diseases.

Chronic inflammation left unchecked is a major factor in “turning on” the chronic disease. Unfortunately, chronic inflammation (also called silent, systemic, or cellular inflammation) most frequently does not have symptoms. The use of appropriate biomarker laboratory tests can help to identify chronic inflammation. View Schematic

The Chronic Inflammation Test measures the activation of the thromboxane A2 pathway, a major component of the inflammation biochemistry pathway. A Chronic Inflammation Test Score that continues to remain significantly elevated is a good sign you are at risk.

Many different therapeutic measures have been shown to reduce chronic inflammation, including lifestyle, dietary, and nutritional modifications. Patients are individuals and as such may have different responses to treatment. One size or one therapy does not fit all.

Residual Inflammatory Risk is a term recently reported by clinical studies. If patients continue to have elevated inflammatory markers in spite of therapy, they are at a very high risk of further negative outcomes. To determine if the steps you are taking to reduce inflammation are working, a simple, non-invasive urine test may be the best way to learn if you have chronic inflammation.

Chronic inflammation develops unsuspected and unchecked as the result of unhealthy habits. Until now, there have been few ways to detect it. The Chronic Inflammation Test measures the levels of 11-dehydrothromboxane B2, an indirect marker of inflammation, in the urine.

The association of chronic inflammation and chronic diseases with elevated levels of 11-dehydrothromboxane B2 (Chronic Inflammation Test) has been extensively reported in medical literature. For example, clinical studies have demonstrated that increased levels of urinary 11-dehydrothromboxane B2 is a predictor of risk for heart attack, stroke, and cardiovascular death.

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How Does the Chronic Inflammation Test Work?

The Chronic Inflammation Test is a simple, non-invasive urine test.

What the Test Measures

The Chronic Inflammation Test is an immunoassay that determines 11-dehydrothromboxane B2 in urine. The 11-dehydrothromboxane B2 level measures thromboxane A2 production associated with inflammation in the body. A urine creatinine test is also performed to calculate a ratio (11-dehydrothromboxane B2/creatinine) and standardize the test for urine concentration. This permits the test to be performed on a random sample.

The urinary 11-dehydrothromboxane B2 is produced by COX 1 & 2 activity on arachidonic acid (Omega-6 fatty acid). Increased 11-dehydrothromboxane B2 has been associated with disorders such as heart disease, peripheral artery disease, stroke, diabetes, cancer, Alzheimer’s disease, and hypertension. Smoking and obesity frequently raise the 11-dehydrothromboxane B2 level.

What is the Chronic Inflammation Score?

The Chronic Inflammation Score is determined by first calculating the ratio of pg 11-dehydrothromboxane B2/mg/dl creatinine. That ratio is then divided by 10. The reference range for the test score is 23-464.

Therapies That May Lower Results

11-dehydrothromboxane B2 becomes reduced with dietary reduction of
arachidonic acid and through substitution with safe Omega-3 fatty
acid-rich foods or supplements. Levels have been shown to be reduced
by many additional therapeutic measures that reduce thromboxane A2,
including the following:

  • Fish Oil (Rich in Omega-3)
  • Polyphenols
  • Flavanoids
  • Ginger
  • Garlic
  • Green Tea
  • Ginkgo Bilboa
  • Chocolate
  • Vitamin E
  • Aloe Vera
  • Red Wine
  • Aspirin
  • Non-steroidal anti-inflammatory drugs
  • Statins